Archive for August, 2011

Targeting Cancer Codependence

Filed in Health Benefits by on August 10, 2011
Targeting Cancer Codependence

Oncogene targeting is a frequent strategy in cancer research. In the July 13, 2011 , issue of Nature, scientists reported preclinical successes using a different strategy: by targeting what they termed a non-oncogene co-dependency. “Normal cells become tumor cells through a variety of genetic alterations,” said co-author Anna Mandinova, explaining the co-dependency concept. Most often, those genetic alterations are mutations, though other changes such as insertions and deletions also occur. By the time it starts dividing uncontrollably, a tumor cell has picked up an average of eight to 12 such mutations. Targeted therapies on the market today usually target such oncogenes directly. But the mutated genes are not the only ones whose expression levels change in cancerous cells. A tumor cell undergoes metabolic changes, and is in a hostile environment of low oxygen and nutrients. And “in order to survive these changes,” Mandinova explained, “the cell . . . starts to overexpress or underexpress housekeeping genes.”

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Mad Dog All Natural Barbecue Sauces

Filed in Ashley Food in the Press by on August 3, 2011
Mad Dog All Natural Barbecue Sauces

Cooking at home can get down right boring. However, the key to success is to include new ingredients in your dishes that you haven’t tried before. Once and awhile when you’re at the grocery store or reading a favorite website and see a review on a seasoning or sauce why not purchase a couple? By putting yourself out there and exposing taste buds and family to new flavors you’re constantly challenging and redefining your food palette. Mad Dog Barbecue Sauces might be just the key to gourmet food right from your home kitchen.

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